A NUMERICAL SHALLOW WATER MODEL BASED ON THE NON-ORTHOGONAL CURVILINEAR GRIDS

ABSTRACT According to the transformation relationships between the Cartesian coordinates and the general curvilinear coordinates, the governing equations of the model are derived as the forms in the general curvilinear coordinates from those in the Cartesian coordinates. In the model, the contravariant velocities are adopted as the independent variables in non-orthogonal grids. The momentum equations keep strongly conservative forms and the boundary conditions can be given easily. The model used a staggered grid arrangement. The discrete equations are solved using the SIMPLIC algorithms. The numerical model has been validated against the bifurcated flow of which the diversion angle is 30 degree. Compared with the measured values, the numerical shallow water model is shown to be capable of simulating the water domains with irregular boundaries

C-Terminus of Progranulin Interacts with the Beta-Propeller Region of Sortilin to Regulate Progranulin Trafficking

Progranulin haplo-insufficiency is a main cause of frontotemporal lobar degeneration (FTLD) with TDP-43 aggregates. Previous studies have shown that sortilin regulates progranulin trafficking and is a main determinant of progranulin level in the brain. In this study, we mapped the binding site between progranulin and sortilin. Progranulin binds to the beta-propeller region of sortilin through its C-terminal tail. The C-terminal progranulin fragment is fully sufficient for sortilin binding and progranulin C-terminal peptide displaces progranulin binding to sortilin. Deletion of the last 3 residues of progranulin (QLL) abolishes its binding to sortilin and also sortilin dependent regulation of progranulin trafficking. Since progranulin haplo-insufficiency results in FTLD, these results may provide important insights into future studies of progranulin trafficking and signaling and progranulin based therapy for FTLD

Superconductivity in epitaxially grown LaVO3/KTaO3(111) heterostructures

Complex oxide heterointerfaces can host a rich of emergent phenomena, and epitaxial growth is usually at the heart of forming these interfaces. Recently, a strong crystalline-orientation-dependent two-dimensional superconductivity was discovered at interfaces between KTaO3 single-crystal substrates and films of other oxides. Unexpectedly, rare of these oxide films was epitaxially grown. Here, we report the existence of superconductivity in epitaxially grown LaVO3/KTaO3(111) heterostructures, with a superconducting transition temperature of ~0.5 K. Meanwhile, no superconductivity was detected in the (001)- and (110)-orientated LaVO3/KTaO3 heterostructures down to 50 mK. Moreover, we find that for the LaVO3/KTaO3(111) interfaces to be conducting, an oxygen-deficient growth environment and a minimum LaVO3 thickness of ~0.8 nm (~ 2 unit cells) are needed.Comment: 5 figures, plus 6 supplementary figure

A Chinese Herbal Formula, Gengnianchun, Ameliorates β

Alzheimer’s disease (AD) is an age-related neurodegenerative disorder, and the few drugs that are currently available only treat the symptoms. Traditional medicine or phytotherapy has been shown to protect against AD. In our previous studies, Gengnianchun (GNC), a traditional Chinese medicine formula with a prolongevity effect, protected against Aβ-induced cytotoxicity in pheochromocytoma cells (PC-12 cells) and hippocampal cells. Here, we investigated the effects and possible mechanisms by which GNC protected against Aβ toxicity using transgenic Caenorhabditis elegans CL4176. Our results showed that GNC effectively delayed the Aβ toxicity-triggered body paralysis of CL4176 worms. GNC decreased Aβ by reducing Aβ mRNA levels. Moreover, GNC significantly reduced reactive oxygen species in the AD model worms compared with the controls. In addition, GNC upregulated the daf-16, sod-3, hsp-16.2 genes, and enhanced DAF-16 translocation from the cytoplasm to the nuclei under oxidative stress conditions. GNC treatment of C. elegans strains lacking DAF-16 did not affect the paralysis phenotype. Taken together, these findings suggest that GNC could protect against Aβ-induced toxicity via the DAF-16 pathway in C. elegans. Further studies are required to analyze its effectiveness in more complex animals

A fully coupled 3D wave-current interaction model on unstructured grids

We present a new modeling system for wave-current interaction based on unstructured grids and thus suitable for very large-scale high-resolution multiscale studies. The coupling between the 3D current model (SELFE) and the 3rd generation spectral wave model (WWM-II) is done at the source code level and the two models share same sub-domains in the parallel MPI implementation in order to ensure parallel efficiency and avoid interpolation. We demonstrate the accuracy, efficiency, stability and robustness of the coupled SELFE-WWM-II model with a suite of progressively challenging benchmarks with analytical solution, laboratory data, and field data. The coupled model is shown to be able to capture important physics of the wave-current interaction under very different scales and environmental conditions with excellent convergence properties even in complicated test cases. The challenges in simulating the 3D wave-induced effects are highlighted as well, where more research is warranted

Extratropical storm inundation testbed: Intermodel comparisons in Scituate, Massachusetts: EXTRATROPICAL STORM INUNDATION TESTBED

The Integrated Ocean Observing System Super-regional Coastal Modeling Testbed had one objective to evaluate the capabilities of three unstructured-grid fully current-wave coupled ocean models (ADCIRC/SWAN, FVCOM/SWAVE, SELFE/WWM) to simulate extratropical storm-induced inundation in the US northeast coastal region. Scituate Harbor (MA) was chosen as the extratropical storm testbed site, and model simulations were made for the 24-27 May 2005 and 17-20 April 2007 (Patriot's Day Storm) nor'easters. For the same unstructured mesh, meteorological forcing, and initial/boundary conditions, intermodel comparisons were made for tidal elevation, surface waves, sea surface elevation, coastal inundation, currents, and volume transport. All three models showed similar accuracy in tidal simulation and consistency in dynamic responses to storm winds in experiments conducted without and with wave-current interaction. The three models also showed that wave-current interaction could (1) change the current direction from the along-shelf direction to the onshore direction over the northern shelf, enlarging the onshore water transport and (2) intensify an anticyclonic eddy in the harbor entrance and a cyclonic eddy in the harbor interior, which could increase the water transport toward the northern peninsula and the southern end and thus enhance flooding in those areas. The testbed intermodel comparisons suggest that major differences in the performance of the three models were caused primarily by (1) the inclusion of wave-current interaction, due to the different discrete algorithms used to solve the three wave models and compute water-current interaction, (2) the criterions used for the wet-dry point treatment of the flooding/drying process simulation, and (3) bottom friction parameterizations

Extratropical storm inundation testbed : intermodel comparisons in Scituate, Massachusetts

Author Posting. © American Geophysical Union, 2013. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Journal of Geophysical Research: Oceans 118 (2013): 5054–5073, doi:10.1002/jgrc.20397.The Integrated Ocean Observing System Super-regional Coastal Modeling Testbed had one objective to evaluate the capabilities of three unstructured-grid fully current-wave coupled ocean models (ADCIRC/SWAN, FVCOM/SWAVE, SELFE/WWM) to simulate extratropical storm-induced inundation in the US northeast coastal region. Scituate Harbor (MA) was chosen as the extratropical storm testbed site, and model simulations were made for the 24–27 May 2005 and 17–20 April 2007 (“Patriot's Day Storm”) nor'easters. For the same unstructured mesh, meteorological forcing, and initial/boundary conditions, intermodel comparisons were made for tidal elevation, surface waves, sea surface elevation, coastal inundation, currents, and volume transport. All three models showed similar accuracy in tidal simulation and consistency in dynamic responses to storm winds in experiments conducted without and with wave-current interaction. The three models also showed that wave-current interaction could (1) change the current direction from the along-shelf direction to the onshore direction over the northern shelf, enlarging the onshore water transport and (2) intensify an anticyclonic eddy in the harbor entrance and a cyclonic eddy in the harbor interior, which could increase the water transport toward the northern peninsula and the southern end and thus enhance flooding in those areas. The testbed intermodel comparisons suggest that major differences in the performance of the three models were caused primarily by (1) the inclusion of wave-current interaction, due to the different discrete algorithms used to solve the three wave models and compute water-current interaction, (2) the criterions used for the wet-dry point treatment of the flooding/drying process simulation, and (3) bottom friction parameterizations.This project was supported by NOAA via the U.S.IOOS Office (award: NA10NOS0120063 and NA11NOS0120141) and was managed by the Southeastern Universities Research Association. The Scituate FVCOM setup was supported by the NOAA-funded IOOS NERACOOS program for NECOFS and the MIT Sea Grant College Program through grant 2012-R/RC-127.2014-04-0